IND Image Gallery

Spinal motor neuron making synapse onto skeletal muscle; blue is motor neuron terminal, red is neurotransmitter receptor on the muscle, and green is Schwann cells.
Image courtesy of Hiroshi Nishimune.

The effects of ibogaine on local cerebral glucose utilization in drug-naive and morphine-dependent rats.
Image courtesy of Beth Levant.

Representative examples of chromosome 15 comparative genomic hybridization (CGH) of individuals with Prader-Willi syndrome and type I or type II deletions using the Agilent 244K CGH microarrays.
Image courtesy of Merlin G. Butler, MD, PhD.

John Ferraro, PhD prepares to perform an Auditory Brainstem Response examination
on a baby to help assess her hearing status.
Photo courtesy of John Ferraro, PhD.

Figure legend: Hematoxylin and eosin stained biceps muscle of a patient with inclusion body myositis. This demonstrates inflammatory cells invading a non-necrotic muscle fiber (green arrow), vacuolated muscle fiber (black arrow), vacuolated myofiber necrosis (yellow arrow) and regeneration (red arrow).
Source: Dr. Mazen Dimachkie

Figure legend: Prader-Willi syndrome study. Region of interest analysis: results of the food vs. baseline contrast in the post-meal condition, comparing patterns of activation in HWC and PWS groups.
Image courtesy of Merlin G. Butler, MD, PhD.

Fragile X syndrome. Network of a subset of genes or gene products known to interact with FMR1. Symbol shape represents functional categories for each gene product.
Image courtesy of Merlin G. Butler, MD, PhD.

Neuropeptides that control feeding behavior are present in the trigeminal ganglion and may be involved in migraine. The neuropeptide ghrelin is shown in green with a marker of neurons involved in pain processing, shown in red.
Image courtesy of Nancy Berman.

Edema after brain injury is imaged using T2 MRI. Edema is slow to resolve in the aged brain after traumatic brain injury.
Image courtesy of Nancy Berman.

After the same injury, the old brain shows greater blood brain barrier opening than the young brain.
Image courtesy of Nancy Berman.

"Gap junction coupling in neuronal developing cultures" An image is from Arumugam et al., Nature Neuroscience, 8 (12) 1720-1726, 2005.
Image courtesy of Andrei B. Belousov

Auditory neurons in the chick brainstem. Propidium iodide (red) staining indicates healthy cells. Neurons destined to die exhibit unusual cytoplasmic staining for a marker of DNA degradation (TUNEL, green label, arrows).
Image courtesy of Dianne Durham

Image of blood vessels in a healing cutaneous wound, with double immunohistochemical labeling showing co-localization of smooth muscle actin and the neurokinin-1 receptor. Our studies have characterized this anatomical substrate as one of many in the healing wound where NK-1 activating neurotransmitters like substance P can act to facilitate closure of the wound.
Image courtesy of Kenneth E. McCarson, Ph.D.

Image showing immunofluorescent labeling of FOS protein, the product of the c-fos immediate early gene, in the dorsal horn of the lumbar spinal cord. This pattern of neuronal activation was evoked by the injection of a painful inflammatory stimulus (dilute formalin) into the ipsilateral hind paw. Markers like this are used throughout our research to quantify the pattern and intensity of cellular activity in the CNS during nociception.
Image courtesy of Kenneth E. McCarson, Ph.D.

Mouse hippocampal neurons cultured and stained for synaptic markers (green and red), and cytoskeleton (blue) by Nishimune laboratory studying synapses.